I use Wekan to manage my tasks. I don't really prioritize them. I do it the GTD way: it is the context, the energy and the desire that determine what I work on. If a task is really crucial, I put it at the top of the list or I put it in red.
I create tasks, especially from the emails I receive, so my inbox is almost always empty.
Tasks that have a fixed deadline also appear in my calendar.
Finally, still in the GTD way, I reserve Friday afternoons for the management of my tasks.